ausEE Inc. has funded nearly $50,000 in medical research grants since 2015 that aims to improve the diagnosis and treatment options for people living with eosinophilic gastrointestinal disorders.
May 2017 - ausEE has awarded additional grant funding of $10,000 to Dr Hamish Philpott and Dr Evan Dellon for the continuing work of their research project titled 'Antigen presentation and acute inflammation in EoE'.
This research is being conducted through the Monash University in collaboration with University of North Carolina, Chapel Hill.
The project aims to measure the immunophenotype of inflammation in the oesophagus following food antigen exposure.
November 2016 - ausEE is pleased to announce that we have awarded grant funding of $8,000 to Dr Hamish Philpott, Dr Evan Dellon and Dr Sanjay Nandurkar for the research project 'Antigen presentation and acute inflammation in EoE'.
This project has the potential to streamline the diagnosis and treatment of patients who present with oesophageal eosinophilia.
We got this lovely message back from Dr Philpott when we let him know their grant application was approved. 'Your support of our research is so vital. We fully comprehend the hard work that goes into organising and fundraising, and faithfully pledge to diligently pursue our work to do justice to your generosity.'
Currently there are few options for the management of these conditions. This study aims to create new targeted drug delivery therapies through the use of nanotechnology.
The study is being conducted at the University of Newcastle, Hunter Medical Research Institute and John Hunter Hospital, and should be complete within the next two years. We look forward to sharing the results with you.
We are grateful for Laureate Professor Nicholas Talley and his team for their dedication to Eosinophilic Gastrointestinal Disorders and wish his team every success.
Are you a physician or researcher wanting to conduct a clinical trial or undertake medical research into eosinophilic gastrointestinal disorders?
To obtain support, please complete our Research Grant Application.
If you have already received funding from ausEE Inc. and require an extension or additional funds please complete our Research Extension Application.
EXPLORING THE EXPERIENCES OF ausEE MEMBERS LIVING WITH EOSINOPHILIC OESOPHAGITIS
On behalf of the Royal Prince Alfred Hospital Allergy Unit we would like to thank members of ausEE for kindly donating their time to participate in a focus group and/or complete a questionnaire. Our research could not have been completed without your contributions.
The research aimed to explore patient views of diagnosis, management and treatment of EoE, including how this journey could be improved. The main areas identified for improvement are summarised below:
The findings from this research have led us to explore the knowledge of dietitians working with patients with EoE as well as looking at developing training and resources to improve dietitian care.
We have also been exploring commonly associated conditions and an alternative dietary testing protocol.
Research Dietitian | Royal Prince Alfred Hospital Allergy Unit
Congratulations to Mary and the Royal Prince Alfred Hospital team on their research into EoE. We are pleased that ausEE and all of our members who so generously donated could be a part of this project.
On behalf of the Department of Clinical Immunology at Royal Prince Alfred Hospital we would like to thank ausEE for their kind donation towards research currently underway. Here Mary Agapides, a scientist working in the department talks about her research.
Our research aimed to find alternate methods of diagnosing EoE and the food allergens potentially involved in causing disease. Currently, the only way to diagnose EoE and monitor the success of treatment, is via endoscopy and biopsy. These procedures are expensive, invasive and can be distressing, particularly as EoE patients often require regular testing to monitor their disease. We were specifically focused on blood tests that could be used to aid in the diagnosis of EoE.
We found two proteins circulating in the blood of EoE patients, eosinophilic cationic protein (ECP) and eosinophil-derived neurotoxin (EDN), that were both indicative of disease. The only problem is, these proteins also seem to appear in individuals with other atopic diseases, such as allergic rhinitis, asthma and eczema, conditions also seen in EoE patients. This means ECP and EDN aren’t ideal to use for an initial EoE diagnosis, however, there is potential for these biomarkers to be used to monitor treatment success in EoE patients.
Dietary manipulation is a popular treatment for EoE, however, deciphering which foods are causing disease is often a lengthy and complicated process. We also found a new potential method of “screening” for food allergens in EoE patients which involved looking in the blood for specific IgE reactions to a large panel of foods. This panel identified new potential problem foods in EoE patients, such as egg yolk, chicken, lamb, orange and fruits that are associated with latex allergies. This new method could also be useful in predicting whether dietary treatment is the best option for an EoE patient and if medication should also be considered in controlling their disease. Our research is continuing to validate this method in a larger group of patient.
Mary performed this work as part of Bachelor of Science (Advanced), Honours Class I (Immunology) at Sydney University.
Page last modified: 27 January, 2018